A recent research reveals that exercise is one of the main reasons behind the decreasing risks of developing colorectal cancer followed by weight loss. According to the research, physical exercise leads to beneficial changes takes place in the bone marrow. The research study is already published in the American Journal of Physiology.
Globally, colorectal cancer is one of the most frequently occurring cancers. Currently, young adults are majorly suffering from this type of cancer in the U.S. As per the previous research conclusions, physical inactivity and obesity raise the risk of occurrence of this type of cancer. However, latest research has investigated that bone marrow cells that further divide to develop blood cells (hematopoietic cells) play an important role in the development of the cancerous tumor majorly in the large intestine in the colon. However, there is no scientific reason yet established that how weight loss through exercise and diet affects bone marrow stem cells and decreases the chances of cancer development.
A team of researchers from the University of Illinois at Urbana-Champaign and the University of Ottawa, Canada studied colorectal cancer in a mouse. A group of mice with developed were supplied with a fat-rich diet and became obese before being provided with a typical rodent diet for studying the relationship between obesity and cancer. After two months of weight loss through rodent diet, half the mice were made to exercise on daily basis and half of them were remained to be inactive.
The scientists identified that even after mice weight loss, the inactive mice were noticed with higher levels of inflammation in bone marrow and colon. The other cause of inflammation is the lack of exercises that cause variation in the hematopoietic cells. The group of mice that were daily exercised was observed less tumor formation and inflammation after weight loss.
The research team concluded that obesity can lead to variation in the microenvironment of bone marrow that remains constant for long-term.